1. Source and History of Qi Ju Di Huang Wan

1. Inheritance of Ancient Recipe

Qi Ju Di Huang Pills are derived from Liu Wei Di Huang Pills in 'Essentials of Pediatric Diseases' written by the famous pediatric expert Qian Yi in the Song Dynasty. Liu Wei Di Huang Pills are composed of six traditional Chinese medicines: Rehmannia glutinosa preparata, Cornus officinalis, Dioscorea opposita, Alisma orientale, Moutan cortex, and Poria cocos. It is the basic formula for nourishing kidney yin. Qian Yi believed that children's 'internal organs are weak, prone to deficiency and excess, cold and heat'. He created Liu Wei Di Huang Pills to nourish kidney yin and regulate children's bodies. Later, on the basis of Liu Wei Di Huang Pills, Zhang Jingyue, a medical expert in the Ming Dynasty, added wolfberry fruit and chrysanthemum in 'Complete Works of Jingyue' to form Qi Ju Di Huang Pills, making its power of nourishing yin and improving eyesight stronger. Since then, Qi Ju Di Huang Pills have been widely used in clinical practice as a classic formula.

2. Historical Use and Development

In the clinical practice of medical experts throughout history, Qi Ju Di Huang Pills have been continuously verified and applied. It is not only used for children but also has good curative effects on various yin deficiency syndromes caused by liver and kidney yin deficiency in adults. Over time, its application scope has gradually expanded, covering multiple fields such as ophthalmology, internal medicine, and gynecology. In ophthalmology, it has significant therapeutic effects on symptoms such as blurred vision and dry eyes caused by liver and kidney yin deficiency; in the field of internal medicine, it can be used to treat dizziness, tinnitus, and deafness caused by liver and kidney yin deficiency; in gynecology, it also has a certain conditioning effect on irregular menstruation and menopausal syndrome caused by liver and kidney yin deficiency. Medical experts throughout history have also continuously summarized experience, optimized and improved the formula, making it more perfect.

2. Introduction of Ingredients (Monarch, Minister, Assistant, Guide)

1. Monarch Ingredient - Prepared Rehmannia Root

Rehmannia glutinosa preparata is sweet in taste and slightly warm in nature, and belongs to the liver and kidney meridians. It is a key medicine for nourishing yin and tonifying blood. It has a sticky texture and can replenish essence and marrow, greatly tonifying the yin of the liver and kidney. In Qi Ju Di Huang Pills, Rehmannia glutinosa preparata serves as the monarch drug, laying the foundation for nourishing yin and tonifying the kidney for the entire formula. It can supplement the deficiency of liver and kidney yin in the human body, making the kidney yin sufficient and the bone marrow nourished, thus playing a role in nourishing the whole body. It is like watering the dry land to allow all things to grow. The medicinal power of Rehmannia glutinosa preparata is mellow and can deeply nourish the liver and kidney, providing strong support for the formula to exert its efficacy.

2. Minister Ingredients - Dogwood Fruit, Chinese Yam

Cornus officinalis is sour and astringent in taste, slightly warm in nature, and belongs to the liver and kidney meridians. It has the functions of tonifying the liver and kidney, astringing and consolidating. It can both nourish the yin of the liver and kidney and astringe essence qi, preventing the leakage of essence qi caused by liver and kidney yin deficiency. In Qi Ju Di Huang Pills, Cornus officinalis assists Rehmannia glutinosa preparata to enhance the power of nourishing yin and tonifying the kidney, and at the same time astringes and consolidates, ensuring that the tonification does not leak, and guaranteeing the stable exertion of the formula's yin-nourishing effect.

Dioscorea opposita is sweet in taste and neutral in nature, and belongs to the spleen, lung, and kidney meridians. It can invigorate the spleen and benefit the stomach, promote the production of body fluid and moisten the lungs, and tonify the kidney and astringe essence. In the case of weak spleen and stomach, Dioscorea opposita can promote the transportation and transformation of the acquired foundation by invigorating the spleen, providing sufficient qi and blood nourishment for the liver and kidney. At the same time, it can also tonify the kidney and astringe essence, synergistically with Cornus officinalis, enhancing the tonifying effect of the formula on the liver and kidney. Dioscorea opposita is like a bridge, connecting the spleen and stomach with the liver and kidney, enabling the qi and blood in the whole body to be generated smoothly and the functions of the internal organs to be coordinated.

3. Assistant Ingredients - Alisma Rhizome, Moutan Bark, Poria

Alisma orientale is sweet and light in taste, cold in nature, and belongs to the kidney and bladder meridians. It can promote diuresis and discharge the turbidity of the kidney. In the process of nourishing yin and tonifying the kidney, drugs such as Rehmannia glutinosa preparata are greasy and prone to hinder the transportation and transformation of the spleen and stomach. Alisma orientale promotes diuresis, enabling the turbid pathogen in the kidney to be excreted through urine, preventing excessive greasiness, and playing a role in discharging the turbidity of the kidney and protecting the spleen and stomach, making the formula tonify without stagnation.

Moutan cortex is bitter and pungent in taste, slightly cold in nature, and belongs to the heart, liver, and kidney meridians. It can clear heat and cool the blood, promote blood circulation and remove stasis. In Qi Ju Di Huang Pills, Moutan cortex can clear away the deficiency heat of the liver and kidney, preventing the generation of internal heat due to yin deficiency. At the same time, its function of promoting blood circulation and removing stasis enables the qi and blood to flow smoothly while nourishing yin, avoiding qi and blood stasis caused by nourishing yin.

Poria cocos is sweet and light in taste, neutral in nature, and belongs to the heart, lung, spleen, and kidney meridians. It can promote diuresis and remove dampness, strengthen the spleen, and calm the mind. On the one hand, Poria cocos assists Alisma orientale in promoting diuresis and removing dampness, strengthening the effect of discharging the turbidity of the kidney; on the other hand, it can strengthen the spleen and calm the mind, preventing the nourishing yin drugs from damaging the spleen and stomach, ensuring the normal transportation and transformation function of the spleen and stomach, and providing a good spleen and stomach environment for the exertion of the formula's medicinal effect.

4. Guide Ingredients - Wolfberry Fruit, Chrysanthemum

Wolfberry fruit tastes sweet and is of neutral nature. It pertains to the Liver and Kidney meridians. It can nourish the Liver and Kidney, and benefit the essence and eyesight. In Qi Ju Di Huang Pills, wolfberry fruit plays a role in enhancing the nourishing effect of the formula on the Liver and Kidney yin and blood. At the same time, its effect on improving eyesight is more prominent. It can directly regulate the eye problems caused by Liver and Kidney yin deficiency, guiding the medicinal power directly to the affected area.

Chrysanthemum tastes pungent, sweet and bitter, and is of slightly cold nature. It pertains to the Lung and Liver meridians. It can disperse wind and clear heat, soothe the Liver and improve eyesight. The addition of chrysanthemum enhances the power of the formula to clear the Liver and improve eyesight. Combined with wolfberry fruit, one tonifies and the other clears. It can not only nourish the yin of the Liver and Kidney, but also clear away the wind-heat of the Liver meridian. It has a good therapeutic effect on symptoms such as dizziness and blurred vision caused by Liver and Kidney yin deficiency combined with upward disturbance of Liver heat. Chrysanthemum is like a guide, leading the medicinal power of the formula to the target of the eyes and exerting the effect of improving eyesight.

III. Pathogenesis, Effects and Indications

1. Pathogenesis

Qi Ju Di Huang Pills The pathogenesis targeted by it is mainly Liver and Kidney yin deficiency. The Kidney is the innate foundation of the body, storing essence and governing water. The Liver is a strong organ, governing dispersion and discharging and storing blood. The Liver and Kidney share the same origin and nourish each other. When Kidney yin is deficient, it cannot nourish the Liver wood, leading to insufficient Liver yin; conversely, insufficient Liver yin can also affect Kidney yin. Liver and Kidney yin deficiency can present various symptoms. For example, deficiency of Kidney yin can cause soreness and weakness of the waist and knees, dizziness and tinnitus, tidal fever and night sweats, etc.; deficiency of Liver yin can cause dryness of the eyes, blurred vision, dull pain in the hypochondrium, etc. In addition, internal heat is generated due to yin deficiency, and the upward disturbance of deficiency heat can also cause symptoms such as restlessness, insomnia, dry mouth and throat.

2. Effects

Qi Ju Di Huang Pills have the effects of nourishing the Kidney and nourishing the Liver, clearing the Liver and improving eyesight. Through drugs such as Rehmannia glutinosa, Cornus officinalis, Dioscorea opposita, etc., they nourish the yin of the Liver and Kidney, making the yin fluid of the Liver and Kidney sufficient and the zang-fu functions restored. Coupled with wolfberry fruit and chrysanthemum to enhance the power of nourishing the Liver and Kidney and clearing the Liver and improving eyesight, it can effectively improve the symptoms of Liver and Kidney yin deficiency. At the same time, Alisma orientale, Moutan cortex, Poria cocos clear away the turbid kidney qi and deficiency heat, preventing excessive greasiness and the generation of heat due to yin deficiency, ensuring the smooth exertion of the nourishing yin effect of the formula, and making the whole body reach the state of yin-yang balance.

3. Indications

Qi Ju Di Huang Pills It mainly treats the syndrome of Liver and Kidney yin deficiency. Common symptoms include dizziness, dryness of the eyes, blurred vision, soreness and weakness of the waist and knees, tinnitus and deafness, tidal fever and night sweats, dry mouth and throat, red tongue with little coating, thready and rapid pulse, etc. In the field of ophthalmology, it can be used to treat senile cataract, glaucoma, macular degeneration, etc. caused by Liver and Kidney yin deficiency; in the internal medicine field, it is commonly used for hypertension, vertigo, neurasthenia, etc. belonging to Liver and Kidney yin deficiency; in gynecology, it can be used for irregular menstruation, menopausal syndrome, etc. of the syndrome type of Liver and Kidney yin deficiency. In short, as long as the disease syndrome is辨证 as Liver and Kidney yin deficiency, Qi Ju Di Huang Pills have a certain therapeutic effect.

IV. Analysis of Formula Principles

1. Tonify Kidney Yin, Fill Essence and Marrow

As the monarch drug, Rehmannia glutinosa greatly nourishes the yin of the Liver and Kidney, replenishes essence and marrow, and is the core drug for nourishing yin in the formula. Cornus officinalis and Dioscorea opposita assist Rehmannia glutinosa to enhance the power of nourishing the Liver and Kidney. Cornus officinalis astringes essence, and Dioscorea opposita tonifies the spleen and benefits essence. The three work together to make the yin fluid of the Liver and Kidney sufficient and the marrow nourished, fundamentally improving the condition of Liver and Kidney yin deficiency.

2. Clear Deficiency Heat, Prevent Greasiness

Alisma orientale, Cortex Moutan, and Poria cocos are adjuvant drugs. Alisma orientale drains the turbid dampness of the kidney, Cortex Moutan clears the deficiency heat of the liver and kidney, and Poria cocos promotes diuresis to excrete dampness, strengthens the spleen, and tranquillizes the mind. They can prevent the nourishing yin drugs such as Rehmannia glutinosa from being greasy and obstructing the spleen, and at the same time clear and discharge the deficiency heat, so that nourishing yin does not generate internal heat, ensuring the normal exertion of the nourishing yin effect of the prescription and maintaining the yin-yang balance of the body.

3. Clear Liver and Improve Vision, Guide Herbs to Meridians

Fructus Lycii and Flos Chrysanthemi are guiding drugs. They can both nourish the liver and kidney and clear the liver and improve eyesight. Fructus Lycii directly nourishes the deficiency of the liver and kidney yin, and Flos Chrysanthemi clears and discharges the wind-heat of the liver meridian. The two work synergistically to enhance the effect of clearing the liver and improving eyesight of the prescription, and at the same time guide the medicinal power of the prescription directly to the eyes, making the prescription more targeted in treating eye diseases caused by liver and kidney yin deficiency.

4. Overall conditioning, treating viscera together

Qiju Dihuang Pills achieve the purpose of overall body conditioning by nourishing the liver and kidney and coordinating the conditioning of other zang-fu organs. Sufficient kidney yin can nourish the liver wood. When the liver wood is nourished, its dredging function is normal, which in turn promotes the transportation and transformation function of the spleen and stomach. At the same time, the effects of clearing deficiency heat, promoting diuresis to excrete dampness, etc. also help to maintain the coordination and balance among the various zang-fu organs of the body, enabling the body to recover to a healthy state.

V. Comparison with other similar prescriptions

1. Comparison with Liuwei Dihuang Pills

Liuwei Dihuang Pills It is the basic prescription for nourishing kidney yin, and its main efficacy is to nourish the kidney and replenish yin. Qiju Dihuang Pills are based on Liuwei Dihuang Pills and added Fructus Lycii and Flos Chrysanthemi, enhancing the effect of clearing the liver and improving eyesight. Liuwei Dihuang Pills focus on simply nourishing the kidney and replenishing yin, and are suitable for patients with liver and kidney yin deficiency but mainly showing symptoms of kidney yin deficiency such as soreness and weakness of the waist and knees, dizziness and tinnitus. Qiju Dihuang Pills are more suitable for patients with liver and kidney yin deficiency accompanied by eye discomfort symptoms such as blurred vision and dry eyes. It can be said that Qiju Dihuang Pills are the extension and expansion of Liuwei Dihuang Pills on the basis of nourishing yin, and are more targeted in treating the situation of liver and kidney yin deficiency with eye symptoms.

2. Comparison with Mingmu Dihuang Pills

Mingmu Dihuang Pills are also prescriptions mainly with the efficacy of nourishing the liver and kidney and improving eyesight. The difference between it and Qiju Dihuang Pills is that while nourishing the liver and kidney, Mingmu Dihuang Pills pay more attention to nourishing blood and improving eyesight, and its composition contains blood-nourishing drugs such as Radix Angelicae Sinensis and Radix Paeoniae Alba. While Qiju Dihuang Pills mainly focus on clearing the liver and improving eyesight, achieving the eyesight-improving effect through the clearing and discharging effect of Flos Chrysanthemi. Therefore, Mingmu Dihuang Pills are suitable for patients with liver and kidney yin deficiency accompanied by blood deficiency symptoms such as dry eyes, blurred vision and sallow complexion; Qiju Dihuang Pills are more suitable for eye problems caused by liver and kidney yin deficiency combined with liver heat disturbing upward, such as dizziness and vertigo, eye distending pain, etc.

3. Comparison with Shihu Yeguang Pills

Shihu Yeguang Pills also have the effects of nourishing the kidney and replenishing yin, clearing the liver and improving eyesight. The difference between it and Qiju Dihuang Pills is that the drug composition of Shihu Yeguang Pills is more complex. In addition to drugs for nourishing the liver and kidney and clearing the liver and improving eyesight, it also contains drugs for nourishing yin and clearing heat such as Herba Dendrobii, Radix Asparagi, and Radix Ophiopogonis, as well as drugs for tonifying qi and strengthening the spleen such as Radix Ginseng and Poria cocos. The medicinal power of Shihu Yeguang Pills is more powerful, and it is suitable for patients with obvious symptoms of yin deficiency and fire hyperactivity of liver and kidney yin deficiency, and at the same time accompanied by qi-yin deficiency, such as dim eyesight, internal obstruction of the eyes, unclear vision and accompanied by dry mouth and throat, fatigue and weakness, etc. While Qiju Dihuang Pills are relatively weaker in medicinal power and more focus on the situation of simple liver and kidney yin deficiency accompanied by mild liver heat disturbing upward.

VI. Clinical applications and indications

1. Ophthalmic diseases

- Senile cataract: As people age, the liver and kidney yin become deficient, the lens gradually becomes cloudy, and vision decreases. Qiju Dihuang Pills can nourish the liver and kidney, delay the process of lens clouding, and improve vision.

- Glaucoma: Deficiency of liver and kidney yin, with flaring of deficient fire, leading to increased intraocular pressure, presenting symptoms such as eye distension, eye pain, and blurred vision. Qi Ju Di Huang Pills can nourish yin and reduce fire, relieve symptoms, and protect the optic nerve.

- Macular lesion: Mostly due to deficiency of liver and kidney yin and insufficiency of qi and blood, resulting in lesions in the macular area. Qi Ju Di Huang Pills can nourish the liver and kidney, nourish blood and improve eyesight, improve the function of the macular area, and enhance vision.

2. Internal medicine diseases

- Hypertension: Deficiency of liver and kidney yin, hyperactivity of liver yang, leading to elevated blood pressure. Qi Ju Di Huang Pills can nourish yin and suppress yang, soothe the liver and lower blood pressure, stabilize blood pressure, and improve symptoms such as dizziness and headache.

- Vertigo: Deficiency of liver and kidney yin, insufficiency of the marrow sea, and failure of the clear orifices to be nourished, causing vertigo. Qi Ju Di Huang Pills nourish the liver and kidney, replenish essence and marrow, relieve vertigo symptoms, and reduce the frequency of attacks.

- Neurasthenia: Prolonged deficiency of liver and kidney yin, resulting in failure of the mind to be nourished, presenting symptoms such as insomnia,多梦, and memory loss. Qi Ju Di Huang Pills can nourish yin and tonify the kidney, calm the mind and soothe the nerves, and improve neurasthenia symptoms.

3. Gynecological Diseases

- Irregular menstruation: Deficiency of liver and kidney yin, insufficiency of the blood sea, leading to irregular menstrual cycle and scanty menstrual flow. Qi Ju Di Huang Pills can nourish the liver and kidney, regulate the thoroughfare and conception vessels, and restore normal menstruation.

- Menopausal syndrome: During menopause in women, deficiency of liver and kidney yin, presenting symptoms such as hot flashes and night sweats, restlessness and insomnia, and mood swings. Qi Ju Di Huang Pills can nourish yin and tonify the kidney, regulate endocrine, and relieve menopausal symptoms.

VII. Modifications

1. Severe Liver-Kidney Yin Deficiency

Nucleus Ligustri Lucidi and Herba Ecliptae can be added to enhance the effect of nourishing yin fluid of liver and kidney. Nucleus Ligustri Lucidi is sweet, bitter, and cool in nature, belonging to the liver and kidney meridians, capable of nourishing the liver and kidney, improving eyesight and blackening hair; Herba Ecliptae is sweet, sour, and cold in nature, belonging to the kidney and liver meridians, capable of nourishing the liver and kidney, cooling blood and stopping bleeding. When combined with Qi Ju Di Huang Pills, deficiency of liver and kidney yin can be more effectively nourished.

2. Obvious Liver Heat Disturbing Upward

Add Prunella vulgaris and Cassia seed to enhance the power of clearing liver-fire. Prunella vulgaris is pungent, bitter, and cold in nature, belonging to the liver and gallbladder meridians. It can clear liver-fire, improve eyesight, and disperse nodules. Cassia seed is sweet, bitter, salty, slightly cold in nature, belonging to the liver and large intestine meridians. It can clear the liver and improve eyesight, moisten the intestine and promote defecation. These two herbs can effectively clear the pathogenic heat in the liver meridian and relieve symptoms such as dizziness and distending pain in the eyes caused by the disturbance of liver-heat upward.

3. With Qi Deficiency

Add Codonopsis pilosula and Astragalus membranaceus to replenish qi and strengthen the spleen. Codonopsis pilosula is sweet, neutral in nature, belonging to the spleen and lung meridians. It can strengthen the spleen and nourish the lung, nourish blood and promote the production of body fluid. Astragalus membranaceus is sweet, slightly warm in nature, belonging to the spleen and lung meridians. It can replenish qi and raise yang, secure the exterior and stop sweating, promote diuresis and alleviate edema. The two can enhance the transportation and transformation function of the spleen and stomach, enabling the production of qi and blood to have a source, and assisting Qiju Dihuang Pills to better exert the effect of nourishing yin.

4. With Blood Deficiency

Add Angelica sinensis and Paeonia lactiflora to nourish blood. Angelica sinensis is sweet, pungent, warm in nature, belonging to the liver, heart, and spleen meridians. It can enrich blood and promote blood circulation, regulate menstruation and relieve pain, moisten the intestine and promote defecation. Paeonia lactiflora is bitter, sour, slightly cold in nature, belonging to the liver and spleen meridians. It can nourish blood and regulate menstruation, astringe yin and stop sweating, soothe the liver and relieve pain. After the improvement of blood deficiency, it helps the recovery of liver-kidney yin deficiency and enhances the therapeutic effect of the formula.

VIII. Dosage (Traditional and Modern Concentrated Granules)

1. Traditional Method

Traditional Qiju Dihuang Pills are generally in pill form, commonly including big honey pills and water-honey pills. Each big honey pill weighs 9 grams, and every 100 water-honey pills weigh 10 grams. The usage is oral administration. Take 1 big honey pill once, or 6 grams of water-honey pills once, twice a day. Take it with warm boiled water when taking. The production process of traditional pills is complex, the content of drug components is relatively stable, and the medicinal effect is long-lasting. However, taking pills is relatively inconvenient, with a large volume, and may not be very suitable for some patients with difficulty in swallowing.

2. Modern Concentrated Granules

Modern concentrated granules of Qiju Dihuang Pills are granule preparations made from traditional formulas through processes such as extraction and concentration. When taking, directly take it with boiling water, 1 bag once, twice a day. Concentrated granules are convenient to take, easy to carry, and can better retain the effective components of the drug. Its dosage has been scientifically adjusted, which better meets the needs of modern clinical medication. However, compared with traditional pills, the storage conditions of concentrated granules have relatively higher requirements, and they need to be stored sealed to prevent moisture and deterioration.

IX. Precautions and Taboos

1. Dietary Taboos

During the period of taking Qiju Dihuang Pills, spicy, greasy, and stimulating foods should be avoided. These foods are likely to generate dampness and transform into heat, aggravating the pathogenic dampness and heat in the body and affecting the nourishing yin effect of the formula. For example, chili, fried foods, alcoholic beverages, etc. should be avoided as much as possible. At the same time, cold and raw foods should also be eaten less to avoid damaging the yang qi of the spleen and stomach, affecting the transportation and transformation function of the spleen and stomach, and further affecting the absorption and efficacy of the drug.

2. Special Populations

Pregnant women should use Qiju Dihuang Pills with caution. Because most of the herbs in the formula are products for nourishing yin, which may have a certain impact on the fetus. Those with deficiency-cold in the spleen and stomach and loose stools are not suitable to take either. The spleen and stomach function of this type of people is relatively weak, and the greasy nature of Qiju Dihuang Pills may further increase the burden on the spleen and stomach, leading to symptoms such as indigestion, abdominal distension, and diarrhea getting worse.

3. Drug Interactions

If taking other medications, consult a doctor or pharmacist before using Qiju Dihuang Pills, because there may be drug interactions. For example, taking it together with Veratrum nigrum may produce adverse reactions, affecting the medicinal effect or increasing toxicity. At the same time, some drugs containing metal ions, such as calcium carbonate, ferrous sulfate, etc., may combine with certain components in Qiju Dihuang Pills, affecting the absorption and efficacy of the drug, and also need to be used with caution.

4. Course of Treatment and Discontinuation

The treatment course of Qiju Dihuang Pills should be determined according to the condition and individual differences. Generally speaking, for those with mild symptoms of liver and kidney yin deficiency, taking it for 2 - 4 weeks may bring certain improvement; for those with severe symptoms, it may be necessary to take it continuously for 1 - 3 months or even longer. However, after the symptoms are significantly improved, it is necessary to consult a doctor in time whether to stop taking the medicine. Do not blindly take it for a long time by yourself to avoid adverse reactions or delaying the condition.

X. Modern Research Progress

1. Research on Pharmacological Effects

Modern research shows that Qiju Dihuang Pills have multiple pharmacological effects. It can regulate the body's immune function, enhance the body's resistance, and has a certain improvement effect on those with low immune function. In terms of its impact on the nervous system, it can regulate the release of neurotransmitters, improve nerve function, and relieve symptoms such as neurasthenia and insomnia. It also has a certain protective effect on the cardiovascular system, can reduce blood pressure, improve myocardial blood supply, and has adjuvant treatment effects on hypertension, coronary heart disease, etc. In addition, Qiju Dihuang Pills also have antioxidant and anti-aging effects, can scavenge free radicals in the body, delay cell aging, and protect the functions of important organs such as the liver and kidney.

Clinical Application Expansion Research

With the development of modern medicine, the clinical application scope of Qiju Dihuang Pills has been continuously expanded. In addition to traditional ophthalmology, internal medicine, and gynecological diseases, it is also applied in the adjuvant treatment of some chronic diseases. For example, in the prevention and treatment of diabetic retinopathy, Qiju Dihuang Pills can delay the progression of the disease and protect eyesight by regulating blood glucose metabolism and improving retinal blood circulation. In patients with chronic renal insufficiency, Qiju Dihuang Pills can improve renal function indicators and improve the quality of life of patients. In addition, in the research on some geriatric diseases such as cognitive dysfunction and osteoporosis, it has also been found that Qiju Dihuang Pills may have certain preventive and therapeutic effects, opening up new fields for its clinical application.

Dosage Form Improvement Research

In order to improve the curative effect of Qiju Dihuang Pills and facilitate patients to take them, a large number of studies have been carried out on the improvement of its dosage forms in modern times. In addition to the concentrated granules mentioned above, it has also been made into dosage forms such as capsules and tablets. While maintaining the medicinal effect, these new dosage forms are more convenient for patients to carry and take, improving the compliance of patients. At the same time, some studies have also explored combining Qiju Dihuang Pills with other drugs to make compound preparations to enhance its therapeutic effect. For example, combined with western medicine antihypertensive drugs in the treatment of hypertension, it can better control blood pressure and reduce the occurrence of adverse reactions.

Quality Control Research

To ensure the stable quality and reliable curative effect of Qiju Dihuang Pills, in-depth research has been carried out on its quality control in modern times. By establishing a complete standard for medicinal materials, production process specifications, and quality inspection systems, it is ensured that the quality of medicinal materials and the preparation process of the prescription meet the requirements. Advanced analytical techniques such as high-performance liquid chromatography and gas chromatography are used to quantitatively determine the active ingredients in Qiju Dihuang Pills, and strictly control the product quality. At the same time, strengthen the research on the stability of drugs, determine their expiration date and storage conditions, and ensure that patients use drugs with qualified quality and definite curative effect.