Digestive Formulas

枳实导滞丸 · Zhǐ Shí Dǎo Zhì Wán

Zhi Shi Dao Zhi Wan

A classical formula for food stagnation with damp-heat, presenting with abdominal distension, constipation or sticky diarrhoea, and a thick yellow greasy tongue coating.

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Last reviewed August 2026
Formula CategoryDigestive Formulas
Primary PatternFood Stagnation
Primary FunctionGuide out stagnation, clear heat, drain damp
Primary Therapeutic PrincipleResolve food accumulation, clear damp-heat and move the bowels
Main HerbsImmature Bitter Orange · Rhubarb Root and Rhizome · Coptis Rhizome · Scutellaria / Baikal Skullcap · Medicated Leaven · White Atractylodes Rhizome · Poria / Hoelen · Alisma Rhizome
Classical SourceNei Wai Shang Bian Huo Lun (Li Dongyuan, Jin dynasty)

Why This Formula?

Traditionally selected for food stagnation combined with damp-heat — stronger clearing than Bao He Wan, more accumulation-focused than pure heat-diarrhoea formulas.

Traditionally selected for food stagnation combined with damp-heat — stronger clearing than Bao He Wan, more accumulation-focused than pure heat-diarrhoea formulas.

What Is Zhi Shi Dao Zhi Wan?

1. A Crystallisation of Ancient Medical Wisdom

Zhi Shi Dao Zhi Wan (枳实导滞丸), or Immature Bitter Orange Pill to Guide Out Stagnation, is a classical Jin-Yuan dynasty formula from Li Dongyuan’s Nei Wai Shang Bian Huo Lun (Clarifying Doubts about Damage from Internal and External Causes). It belongs to the category of formulas that reduce food stagnation and clear Damp-Heat.

This formula addresses food stagnation that has transformed into Damp-Heat accumulation in the Stomach and Intestines. Typical signs include abdominal distention and pain (especially after eating), constipation or foul-smelling loose stools with tenesmus, reduced appetite, foul belching, a yellow greasy tongue coating, and a slippery rapid pulse.

 Led by Zhi Shi to strongly move Qi and break up stagnation, combined with Da Huang to purge accumulation downward, Huang Lian and Huang Qin to clear Damp-Heat, and supportive herbs such as Shen Qu, Bai Zhu, Fu Ling, and Ze Xie, Zhi Shi Dao Zhi Wan guides out stagnant food, drains Heat and Dampness, and restores digestive function.

Zhi Shi Dao Zhi Wan: Dispersing Accumulation, Guiding out Stagnation, Clearing Heat and Resolving Dampness for Constipation, Bloating and Indigestion | HJMEDICAL

2. Indigestion

Zhi Shi Dao Zhi Wan is an excellent choice for treating indigestion that stems from poor eating habits. You might consider this if you experience:

  • Symptoms: Feeling uncomfortably full or bloated in the upper stomach, losing your appetite, belching with a "rotten" or foul odor, and suffering from acid reflux.
  • How it helps: Zhi Shi and Da Huang work to move energy and physically flush out the stagnant food, while Shen Qu helps your stomach process what remains. This effectively clears the "backlog" in your digestive tract and helps your system get back to normal.

3. Gastroenteritis

For cases of gastroenteritis (stomach flu) caused by "damp-heat" in the gut, this formula offers significant relief.

  • Symptoms: Abdominal pain, diarrhea, and stools that feel "sticky" or difficult to pass completely. You may also notice a thick, yellow, greasy coating on your tongue.
  • How it helps: Its triple action of clearing heat, drying dampness, and moving Qi targets the inflammation directly. It helps reduce the frequency of diarrhea, calms abdominal cramps, and restores healthy gastrointestinal function.
Zhi Shi Dao Zhi Wan

4. Dysentery

In the early stages of dysentery, particularly when it is characterized by "damp-heat," Zhi Shi Dao Zhi Wan is a staple treatment.

  • Symptoms: Sharp abdominal pain, a constant but frustrated urge to have a bowel movement (tenesmus), stools containing mucus or blood, a burning sensation in the rectal area, and a yellow, greasy tongue coating.
  • How it helps: The "Three Yellows" (Da Huang, Huang Lian, and Huang Qin) work like a powerful internal cooling system to drain fire and detoxify the intestines. Meanwhile, Zhi Shi guides the stagnant energy downward, effectively eliminating the pathogens causing the infection and relieving the distressing symptoms.

Herb Composition (Sovereign / Minister / Assistant / Envoy)

1. Chief Herb: Zhi Shi (Immature Bitter Orange)

Zhi Shi is the "leader" of this formula. It is bitter, spicy, and slightly cooling, targeting the Spleen, Stomach, and Large Intestine.

  • Breaking Blockages: Its primary job is to break up stagnant energy (Qi) and disperse physical accumulation. Think of it as a powerful tool that clears out the "stuck" feeling in your digestive tract.
  • Moving Things Down: It is an expert at directing energy downward. This makes it highly effective for treating bloating, abdominal pain, and difficult bowel movements caused by gas and food getting stuck in the gut.
  • Rapid Action: Because its action is relatively strong, it quickly gets the digestive "traffic" moving again so that buildup can be cleared out.

2. Deputy Herb: Da Huang (Rhubarb Root)

Da Huang is the formula's "heavy lifter" for detoxification and purging. It is bitter and cold with a strong downward-moving nature.

  • The Purger: Its main role is to sweep away excess heat and stagnation. It works like a broom for your intestines, eliminating old, stuck material to make room for fresh energy.
  • Powerful Synergy: When paired with Zhi Shi, it significantly strengthens the formula's ability to guide out stagnation and flush toxins from the body.
  • Targeted Relief: Because it reaches directly to the lower part of the body, it is excellent for relieving constipation, abdominal pain, and that "thick, yellow, greasy" coating on the tongue that signals internal damp-heat.

3. Assistant Herbs: Huang Lian and Huang Qin

These two herbs—both members of the "Yellow" family—are specialists at clearing heat and drying out dampness.

  • Huang Lian: Focuses on clearing damp-heat from the middle part of the body (the stomach area).
  • Huang Qin: Tends to focus on the upper body and the large intestine.
  • The Balancing Act: Together with Da Huang, they aggressively eliminate the "swampy" damp-heat environment that causes diarrhea and dysentery. Importantly, their presence helps mellow out the fierce nature of the chief herbs, ensuring the formula clears the sickness without being too harsh on your body's healthy energy.
Zhi Shi Dao Zhi Wan: Dispersing Accumulation, Guiding out Stagnation, Clearing Heat and Resolving Dampness for Constipation, Bloating and Indigestion | HJMEDICAL

4. Envoy Herb: Shen Qu (Medicated Leaven)

Shen Qu is the "harmonizer" that keeps your digestion stable. It is sweet, spicy, and warming.

  • Digestive Aid: Its main job is to help digest food and strengthen the Spleen. It ensures that while the other herbs are busy "purging" the bad stuff, your body can still process nutrients properly.
  • The Protector: It acts as a shield for your Spleen and Stomach, preventing the stronger purging herbs from accidentally weakening your digestive energy.
  • Gentle Regulation: Because its action is mild and restorative, it helps regulate your long-term digestive health and keeps your appetite healthy during recovery.

Clinical Presentation in TCM

1. Pathomechanism Analysis

The core problem Zhi Shi Dao Zhi Wan addresses is a "digestive traffic jam" caused by damp-heat and food accumulation.

  • How it starts: This usually happens because of irregular eating habits—like eating too much greasy, spicy, raw, or cold food.
  • The internal "Swamp": When your Spleen and Stomach can't keep up with the workload, food gets stuck. Over time, this stagnant food ferments and turns into "damp-heat," which is like a hot, sticky blockage in your gut.
  • Qi Blockage: This sticky mess blocks the natural flow of your body's energy (Qi), leading to symptoms like intense bloating, abdominal pain, and that uncomfortable "yellow, greasy" coating on your tongue.

2. Actions

This formula acts as a comprehensive "clean-up crew" for your digestive tract by performing these key actions:

  • Breaking up Stagnation: Using herbs like Zhi Shi and Da Huang, it physically pushes out the food that is stuck and directs the body's energy downward.
  • Clearing Heat and Dampness: Huang Lian and Huang Qin act as cooling and drying agents to eliminate the "swampy" environment caused by the fermentation of food.
  • Aiding Digestion: Shen Qu helps your stomach actually process what’s left, ensuring your digestive system gets back to its normal routine.
Zhi Shi Dao Zhi Wan: Dispersing Accumulation, Guiding out Stagnation, Clearing Heat and Resolving Dampness for Constipation, Bloating and Indigestion | HJMEDICAL

3. Indications

Zhi Shi Dao Zhi Wan is primarily used when you feel "backed up" and inflamed. You might consider it if you have:

  • Digestive Discomfort: Feeling full and bloated in the upper or lower abdomen, often with pain.
  • Appetite and Bowel Issues: A total loss of appetite, constipation, or even diarrhea where you feel like you haven't "finished" (tenesmus).
  • Common Conditions: It is frequently used for gastroenteritis, dysentery, or general digestive disorders where there is significant inflammation and food stagnation.

Essentially, it clears out the "trash" and cools down the "fire" in your gut so you can feel light and comfortable again.

The Mechanism in Classical Theory

1. Combined Use of Qi-Moving and Purgative Actions

This formula uses a "double-action" approach to get your digestion moving again:

  • The Descent: Zhi Shi breaks up stagnant energy and pushes it downward.
  • The Flush: Da Huang acts as a powerful cleanser to physically purge the buildup.
  • The Result: Together, they create a strong downward force that quickly clears out "stuck" food and gas. This "one-two punch" directly fixes the root cause of bloating and constipation by restoring the natural downward flow of your digestive energy.

2. Combination of Heat-Clearing and Dampness-Drying

To fix an inflamed gut, you need to cool it down and dry it out.

  • The Firefighters: Huang Lian and Huang Qin act as the primary cooling and drying agents.
  • The Cleanse: When combined with Da Huang, they not only flush out the bad stuff but also prevent the "damp-heat" (inflammation) from sticking to your intestinal walls.
  • The Result: This combination is what makes the formula so effective at stopping diarrhea and dysentery, leaving your stomach and intestines feeling "fresh" and clear again.
Zhi Shi Dao Zhi Wan

3. Attending to Both Digestion and Spleen-Strengthening

A common problem with strong "purging" formulas is that they can be too harsh on your system. Zhi Shi Dao Zhi Wan avoids this problem by including Shen Qu.

  • Support and Protect: While the other herbs are busy attacking the blockages, Shen Qu works to support your Spleen and boost your appetite.
  • Balance: It ensures that your body stays strong enough to actually digest food once the blockage is gone.
  • The Principle: This perfectly illustrates the traditional healing rule of "combining attack with supplementation"—getting rid of the sickness while keeping the body strong.

Clinical Comparison Table

Compare Zhi Shi Dao Zhi WanBao He WanMu Xiang Bing Lang WanGe Gen Qin Lian Tang
Primary Function Guide out stagnation, clear heat, drain dampPromote digestion, resolve food stagnationMove Qi, guide out stagnation, purge accumulationRelease exterior, clear interior heat, stop diarrhoea
Formula Category Digestive FormulasDigestive FormulasDigestive FormulasHeat-Clearing Formulas
Typical TCM Pattern Food StagnationFood StagnationFood StagnationDamp-Heat
Main Conditions Bloating, Abdominal Pain, Diarrhea, Indigestion, ConstipationIndigestion, Bloating, Poor Appetite, Stomach Discomfort, Acid Reflux, DiarrheaBloating, Abdominal Pain, Constipation, Indigestion, Poor AppetiteDiarrhea, Fever, Abdominal Pain, Dry Mouth & Throat
Main Herbs Immature Bitter Orange · Rhubarb Root and Rhizome · Coptis Rhizome · Scutellaria / Baikal Skullcap · Medicated Leaven · White Atractylodes Rhizome · Poria / Hoelen · Alisma RhizomeHawthorn Fruit · Medicated Leaven · Radish Seed · Pinellia Rhizome · Tangerine Peel · Poria / Hoelen · Forsythia FruitAucklandia / Costus Root · Areca Seed · Green Tangerine Peel · Tangerine Peel · Curcuma Rhizome · Pharbitis Seed · Rhubarb Root and Rhizome · Coptis Rhizome · Phellodendron BarkKudzu Root · Scutellaria / Baikal Skullcap · Coptis Rhizome · Honey-fried Licorice
Classical Source Nei Wai Shang Bian Huo Lun (Li Dongyuan, Jin dynasty)Dan Xi Xin Fa (Zhu Danxi, Yuan dynasty)Ru Men Shi Qin (Zhang Congzheng, Jin dynasty)Shang Han Lun (Zhang Zhongjing, Eastern Han)

How to tell them apart

Zhi Shi Dao Zhi Wan clears damp-heat while guiding food stagnation. Bao He Wan is milder for simple food stagnation. Mu Xiang Bing Lang Wan more strongly moves Qi and purges. Ge Gen Qin Lian Tang clears heat for feverish diarrhoea with exterior signs.

For educational reference only, based on traditional pattern differentiation — not a substitute for professional advice.

Clinical Modifications for Zhi Shi Dao Zhi Wan

1. With Pronounced Qi Stagnation

If the feeling of bloating and "stuck" energy is particularly strong, doctors may add Mu Xiang (Costus Root) and Hou Po (Magnolia Bark) to give the formula more "push."

  • Mu Xiang: This herb is a specialist at moving Qi and relieving pain. It helps unlock stagnant energy in the gut.
  • Hou Po: This herb is excellent for relieving fullness. It helps dry out dampness and forces rebellious energy to move downward.
  • The Result: When these work with Zhi Shi, they create a powerful synergistic effect that more effectively clears out the gas and pressure caused by deep energy blockages.

2. With Concurrent Spleen Deficiency

If a patient is already feeling weak or has a naturally fragile digestive system, herbs like Bai Zhu (Atractylodes Rhizome) and Dang Shen (Codonopsis Root) are added to protect their energy.

  • Bai Zhu: This herb strengthens the Spleen and helps dry out excess moisture, keeping the digestion stable.
  • Dang Shen: This is a classic energy booster (Qi tonic) that supports the "middle" of the body.
  • The Result: Along with Shen Qu, these herbs ensure that the formula doesn't over-purge the body. This follows the traditional principle of "combining attack with supplementation," making it safe for people who are sick but also physically drained.
Zhi Shi Dao Zhi Wan

3. With Pronounced Damp-Heat

When the "swampy" inflammation is severe—indicated by intense diarrhea and dark, concentrated urine—herbs like Hua Shi (Talcum) and Che Qian Zi (Plantago Seed) can be added to help drain the heat.

  • Hua Shi: This herb clears heat and promotes urination. It helps flush toxins out of the body through the urine.
  • Che Qian Zi: This seed is excellent at draining dampness and clearing heat from the lower body.
  • The Result: Together, they strengthen the formula's ability to clear the internal "swamp," allowing damp-heat pathogens to leave the body faster. This provides quick relief for diarrhea and helps restore normal, clear urination.

What the Science Suggests

Zhi Shi Dao Zhi Wan (枳實導滯丸) is a classical formula that breaks up stagnant qi, reduces accumulation, and unblocks the bowels.

It effectively addresses qi obstruction with abdominal distention, gas, and food stagnation, while it also transforms phlegm. The formula is particularly useful when excess accumulation occurs on a background of spleen and stomach deficiency, helping to clear stagnation without overly damaging the middle jiao.

1. Pharmacological Research

Modern scientific studies have shown that Zhi Shi Dao Zhi Wan works through several biological mechanisms to improve digestive health:

  • Improving Digestion Flow: Research indicates that the active components in Zhi Shi can stimulate the smooth muscles of the gut, enhancing peristalsis (the wave-like movements of the intestines). This helps the stomach and intestines empty more efficiently.
  • Powerful Cleansing: Da Huang works by stimulating the nerve plexus in the intestines, which increases the "propulsive" movement needed to clear out waste and blockages.
  • Natural Antibacterial Action: Both Huang Lian and Huang Qin have been proven to have antibacterial and anti-inflammatory properties. They help inhibit the growth of harmful bacteria in the gut and calm down the body's inflammatory response.

These actions confirm the formula's ability to regulate gastrointestinal motility while clearing out infections.

Zhi Shi Dao Zhi Wan

2. Expansion of Clinical Applications

As modern medicine takes a closer look at digestive disorders, the use of Zhi Shi Dao Zhi Wan has expanded beyond its traditional roots:

  • Modern Gut Health: In addition to treating classic indigestion and gastroenteritis, it is now being used to manage functional dyspepsia (chronic indigestion with no obvious cause) and Irritable Bowel Syndrome (IBS).
  • Combined Therapies: Clinical trials have shown that when this formula is used alongside Western medical treatments or acupuncture, patients often see even better results. This collaborative approach offers more flexible and effective options for treating complex digestive issues.
  • Symptom Relief: Ongoing studies continue to confirm its value in improving general gastrointestinal dysfunction, helping patients find relief from chronic bloating and discomfort.

Safety Considerations

1. Cautions & Contraindications

Zhi Shi Dao Zhi Wan has strong purgative and qi‑moving actions—use with caution in those with weak constitutions or spleen‑stomach deficiency‑cold, as it may deplete upright qi and cause/worsen abdominal pain or diarrhea. It is contraindicated in pregnancy (contains purgative herbs like Dahuang) due to risk of miscarriage or preterm labor.

2. Dietary Precautions

During treatment maintain a light diet and avoid spicy, greasy, raw, and cold/irritating foods to reduce GI burden and support herb absorption; keep regular meals and avoid overeating.

Questions About Zhi Shi Dao Zhi Wan

Q1: What are the actions of Zhi Shi Dao Zhi Wan?
Zhi Shi Dao Zhi Wan has the actions of reducing and guiding out food stagnation and accumulation, draining Heat, and dispelling Dampness. It is designed for excess patterns of food accumulation complicated by Damp-Heat in the Middle Jiao.
Q2: Which modern diseases is Zhi Shi Dao Zhi Wan suited to?
Modern TCM clinical practice commonly applies it to individuals whose pattern differentiation falls within food stagnation with Damp-Heat, including acute indigestion or food stagnation after overeating, acute gastroenteritis or bacterial dysentery with Damp-Heat signs, functional dyspepsia with abdominal distension and Heat, and certain cases of constipation or foul diarrhea of accumulation type.
Q3: Is Zhi Shi Dao Zhi Wan suitable for improving abdominal distension, foul stools, and poor appetite after dietary excess?
For presentations of epigastric or abdominal distension and pain (worse after eating), constipation or diarrhea with foul-smelling stools, possible tenesmus, dark scanty urine, a greasy yellow tongue coating, and a deep forceful pulse — in those whose pattern differentiation confirms food stagnation with Damp-Heat — TCM commonly applies Zhi Shi Dao Zhi Wan as an adjunct. It cannot replace standard medical treatment.
Q4: Who should not take Zhi Shi Dao Zhi Wan?
Those who are pregnant, have Spleen-Stomach deficiency Cold, pure deficiency without accumulation, or chronic deficiency-type diarrhea without Heat and stagnation signs are generally not suitable. The formula is draining and contains Da Huang; it is intended for excess patterns only. Use should be assessed by a qualified TCM physician.
Q5: Why can this formula be used for both constipation and diarrhea?
When food stagnation and Damp-Heat obstruct the Intestines, the result may be either blocked bowel movement (constipation) or forced, foul, incomplete diarrhea with tenesmus. By guiding out the stagnation and clearing Damp-Heat, the formula removes the obstruction, allowing normal bowel function to return in either presentation (the classical “tong yin tong yong” approach for dysentery with accumulation).
Q6: Can Zhi Shi Dao Zhi Wan help after overeating rich or greasy foods?
Yes, when the overeating leads to clear signs of food stagnation combined with Damp-Heat (distension, foul belching or stools, greasy yellow tongue coating). It is particularly suited to acute accumulation patterns rather than simple temporary fullness without Heat or Damp signs.
Q7: What are the main ingredients of Zhi Shi Dao Zhi Wan?
Key herbs include Zhi Shi (Immature Bitter Orange) to break Qi stagnation and guide out accumulation; Da Huang to drain Heat and purge stagnation; Huang Lian and Huang Qin to clear Damp-Heat; Shen Qu to transform food stagnation; Bai Zhu to protect the Spleen; and Fu Ling and Ze Xie to drain Dampness. The combination addresses both the accumulation and the accompanying Damp-Heat.
Q8: Is Zhi Shi Dao Zhi Wan suitable for long-term use?
No. It is a short-term formula for excess accumulation patterns. Once the stagnation and Damp-Heat are resolved and bowel function normalizes, the formula should be stopped. Prolonged use of its draining herbs can injure Spleen and Stomach Qi.
Q9: How does this formula differ from pure purgative formulas such as Da Cheng Qi Tang?
Da Cheng Qi Tang strongly purges Yangming Heat and dryness with constipation as the primary focus. Zhi Shi Dao Zhi Wan is milder, specifically targets food stagnation plus Damp-Heat, and can address either constipation or dysentery-like diarrhea. It also includes herbs to transform food and protect the Spleen, making it more suitable for mixed accumulation patterns.
Q10: What lifestyle advice supports the use of Zhi Shi Dao Zhi Wan?
Avoiding further overeating, greasy, spicy, or heavy foods, choosing light and easily digestible meals, and resting the digestive system help the formula clear accumulation and Damp-Heat. Once acute symptoms resolve, focus shifts to gentle dietary regulation to prevent recurrence. Professional medical evaluation is important for severe or persistent abdominal symptoms.

General Questions

How do I choose the right formula?
TCM formulas are traditionally selected according to individual pattern differentiation rather than by symptom alone. If you're not sure which formula fits your presentation, take our AI Assessment below for a personalized starting point, then confirm with a qualified TCM practitioner.
What are concentrated herbal granules?
Concentrated herbal granules are made by decocting raw herbs, then extracting and concentrating the resulting liquid into a fine granule or powder form. This preserves the same active compounds as a traditional decoction while making the herbs far easier to store, measure, and prepare.
How should I take these products?
Dissolve the recommended amount of granules in hot water, stir until fully dissolved, and drink while warm — following the dosage and frequency advised by your TCM practitioner or as stated on the product packaging.
Are concentrated herbal granules equivalent to traditional decoctions?
Concentrated granules are produced from the same herbs and processed to retain their active compounds, so they are traditionally regarded as a convenient alternative to decoctions rather than a different remedy. Some practitioners note subtle differences in strength or absorption between the two forms, so your TCM practitioner may adjust dosage accordingly.
Are your products authentic?
Yes. HJMEDICAL sources its concentrated granules exclusively from established, reputable manufacturers such as Nong's and Hoi Tin, both long-standing names in the TCM granules industry, with GMP compliance stated directly on their packaging.
Are HJMEDICAL products manufactured under GMP standards?
HJMEDICAL sources its concentrated granules from established, reputable manufacturers such as Nong's and Hoi Tin, both long-standing names in the TCM granules industry. GMP compliance for these products is stated directly on their packaging.
Do you ship internationally?
Yes — we ship worldwide! Every order goes out via Hong Kong Post, and your exact shipping cost and estimated delivery time for your address are calculated and shown right at checkout, so there are never any surprises. We also offer free shipping once your order reaches our free-shipping threshold, so it's easy to stock up on your favorite formulas and save.
Can I take more than one formula at the same time?
Some formulas are traditionally combined, while others overlap or counteract each other. We recommend checking with a qualified TCM practitioner before combining formulas, especially if you are already taking other medication.
Are these products suitable during pregnancy or breastfeeding?
Some TCM formulas are not suitable during pregnancy or breastfeeding. Please consult a qualified TCM practitioner or your doctor before use if you are pregnant, trying to conceive, or nursing.
Do these products replace medical treatment?
No. These products are traditional herbal supplements intended to support wellbeing according to TCM principles — they are not a replacement for professional medical diagnosis or treatment. Please consult a qualified TCM practitioner or licensed healthcare provider before starting, stopping, or combining any treatment, especially if you have a chronic condition.
Medical Disclaimer

For general TCM education only — not medical advice. Consult a qualified TCM practitioner or licensed healthcare provider before use, especially if pregnant, nursing, on medication, or managing a chronic condition.

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Zhi Shi Dao Zhi Wan: Classic TCM Formula for Food Stagnation, Abdominal Fullness & Damp-Heat